Diindolylmethane DIM, in short is the principal breakdown product of indole 3-carbinol I3C , the phytochemical found in cruciferous vegetables like cabbage, cauliflower, broccoli, brussel sprouts, kale, collards, mustard greens, radishes, watercress, and turnips. It relieves PMS and painful periods, and alleviates peri-menopausal, menopausal and postmenopausal symptoms. Progesterone is important for healthy hormonal function and helps provide protection against cell proliferation in estrogen-sensitive tissue.
DIM has no estrogenic activity in itself. Although it helps to convert estrogen to useful metabolites, it does not directly mimic or replace estrogen.
Using DIM will promote a more desirable estrogen metabolism, but it will not make up for estrogen deficiency. Maca alone however, can be successfully used as a hormone balancer, reducing or eliminating hot flashes, vaginal dryness, depression due to low estrogen, supporting a healthy libido, without any of the dangerous side effects of estrogen supplementation HRT.
The Maca-DIM combination is particularly helpful for both reducing the risk of developing an estrogen-dependent cancer as well as with relieving hot flashes and other menopausal symptoms. Furthermore, this combination supports the health of the adrenal glands, thyroid, pancreas and neurotransmitter hormone production, including melatonin. DIM helps women optimize their estrogen metabolism. What makes optimal estrogen metabolism so important for women?
These metabolites help lower the risk of cancer and decrease the symptoms of estrogen over-stimulation, or dominance-symptoms of which include breast tenderness, rapidly growing uterine fibroid tumors, uterine cervix problems as seen with abnormal PAP smears and endometriosis, a painful condition caused by persistent uterine tissue growing in abnormal locations within the abdomen.
These include heart disease, arthritis, and cancer. They are important in preserving the activity of the small amount of testosterone present in all women. This provides additional support fat utilization, as well as support for mood and libido.
Healthy levels of testosterone in women may also help to reduce the symptoms of premenstrual syndrome. How does proper hormonal balance help with weight loss? The effects of free testosterone in women and men are similar. In each case, testosterone promotes the building of new protein. When hormonal balance shifts to favor building new proteins, metabolite rate is increased and fat metabolism is promoted.
Part of the protein-building effect of testosterone is to gear up the cellular enzymes needed to burn fat. Fat contains the stored energy needed to support formation of new proteins as well as the fuel for sustained aerobic exercise.
Together with exercise DIM provides the best hormonal balance to create the protein machinery for active fat utilization. The good estrogen metabolites also directly facilitate the release of stored fat in a number of ways. First, these metabolites assist the specific fat-burning hormones called catecholamines that are produced during exercise to release stored fat.
These released fatty acids circulate in the blood stream as a primary energy source. As circulating catecholamines released during exercise occupy these receptors, stored fat is more actively released from fat cells. The following abstracts of published scientific studies involve the consumption by human being and animals of indolecarbinol. The conversion to DIM occurs in the stomach of living beings in the presence of sufficient stomach acid.
Because estrodial metabolism is also cytochrome P mediated and linked to breast cancer risk, indoles may similarly reduce estrogen-responsive tumors in humans. The most potent inducer common Indole carbinol, was administered to humans mg daily for 1 wk. Most precancerous lesions of the cervix are treated with surgery or ablative therapy.
Chemoprevention, using natural and synthetic compounds, may intervene in the early stages of the carcinogenesis and prevent the development of invasive disease.
HPV status was assessed in all patients. None 0 of 10 of the patients had complete regression of CIN. This protective effect of IC is shown by a relative risk RR of 0. There was statistically significant regression of CIN in patients treated with IC compared with placebo.
Dietary I3C increased the cytochrome P content measured in hepatic microsomes, as well as the extent of estrodial 2-hydroxylation up to 5-fold. Mammary tumor incidents and multiplicity were significantly lower at both doses of I3C and tumor latency was prolonged in the high dose group.
This protective effect may be mediated in part by the increase in part 2- hydroxylation and consequent in activation of endogenous estrogens.