Izzie falls in love with cardiothoracic patient Denny Duquette Jeffrey Dean Morgan , and the two become engaged. When Denny's condition deteriorates, Izzie deliberately worsens his health further by cutting his LVAD wire to move him up the donor register. He supports Izzie when her daughter Hannah Liv Hutchings , diagnosed with leukemia , arrives at Seattle Grace Hospital in need of a bone marrow transplant from Izzie.
She is also handed primary responsibility for the clinic, as Bailey cuts back on her responsibilities. The fifth season ends with her friends ignoring her DNR order and attempting to resuscitate her, transposed with images of Izzie in an elevator encountering George, who has been in an accident and is also currently flatlining.
Believing Alex is partially to blame, she writes him a Dear John letter and leaves. Izzie informs Alex that she no longer has cancer. Although he is pleased, Alex officially breaks up with Izzie, telling her that he loves her but deserves better. She leaves Seattle to start fresh. Imagining that Meredith's half-sister Lexie Chyler Leigh is Izzie, he apologizes and asks her never to leave him again. Development[ edit ] Casting and creation[ edit ] Heigl refused to be considered for the Emmy Awards due to insufficient material on Grey's Anatomy.
Heigl originally wanted to play Izzie as a brunette, but was requested to retain her natural blond for the part. Knight were set to depart from the show,  but he later retracted his comment. Following the show's one-hundredth episode wrap party, Heigl revealed she did not know if Izzie would survive, as no one on the production team would disclose her character's fate to her.
He said, "[Katherine] thinks her Jan. When I was playing the scene I was really trying to convey that, for Izzie, that was a lie that she had to tell herself to have the courage to have to move on. So if she [Katherine] were to come back, we would be thrilled to [wrap up her story]. But if she doesn't, we'll just move on.
I just want to know what happened to her and where she went and what she's doing now. My idea is that she actually like figures it out, and finds some success and does really well in a different hospital. She was always floundering you know, and so she was always one step behind the eight ball and I want to see that girl take some power back.
I miss my friends. It was a great work environment I spent six years together with these people every day I want them to know that I'm down with it if they want me to, but I completely understand if it doesn't necessarily work They've got a lot of story lines going on there. At the same time we are on a track we have been planning.
The idea of changing that track is not something we are interested in right now. Rhimes explained that Izzie's character in this episode came "full circle" from her role in the pilot: She lost her optimism. She realizes now that life is difficult, but she still tries very hard to see the best in people.
And he really screwed her over. I love their relationship because it's so pure and honest and completely game free. Is she tremendously irresponsible? She cut the LVAD wire for love so does that make her action understandable? Knight , deeming it "a ratings ploy". Everyone in dark colors, everyone dressed somberly. As if they were in mourning. Only Izzie is in happy pink. Rhimes explained that "Izzie doesn't sleep around". He can do honorable things even though he's cutting and sarcastic.
I would like to ultimately see them together, if not this season, then next. Voices wrote that Stevens in the third season "has become more condescending and passive aggressive herself, more than anyone else. I have a really hard time with that kind of thing. I'm maybe a little too black and white about it. I don't really know Izzie very well right now. She's changed a lot. People who are so infallible, perfect and moral tend to be the first to slip and fall. Showrunner Shonda Rhimes puts a lot of pressure on Heigl to carry many intense storylines, and she's up to the challenge.
He deemed her the show's heroine, and wrote that: Bailey Chandra Wilson , Izzie seems to be the only adult intern at Seattle Grace; the character has achieved a depth lacking in her fellow interns. Otis Brawley, chief medical officer at the American Cancer Society , commented that Izzie's treatment options were unrealistic. Whereas in the show she was offered the drug interleukin-2 , in reality the drug is never recommended to patients when melanoma has spread to the brain, as it can cause bleeding and strokes.
Brawley explained that such patients would instead be offered radiosurgery. Parriott writer , Adam Davidson director April 17, Archived from the original on October 21, Retrieved September 6, Archived from the original on May 30, Bardin, Brantley November Retrieved May 9, Archived from the original on March 16, Archived from the original on May 5, Heigl Is Staying on Grey's".
Retrieved July 21,